HPV is the most common sexually transmitted infection in the United States. HPV is so common that nearly all sexually active men and women contract the virus at some point in their lives. In the United States, more than 42 million people are infected with the types of HPV known to cause disease, and an estimated 13 million new HPV infections occur every year among people age 15 through 59 years. Approximately half of new infections occur among people age 15 through 24 years. The first HPV infection typically occurs within a few months to years of becoming sexually active.