Globally, about 59,000 human rabies deaths occur each year, and 98% of these deaths are caused by the canine (dog) rabies virus variant. In the United States, the canine rabies virus variant has been eliminated, but wildlife variants (such as bat, raccoon, and skunk rabies virus variants) remain. Hawaii is the only U.S. state that is rabies-free. About 5,000 animal cases of rabies are reported each year in the United States. In the 21-year period between January 2000 and December 2020, 52 cases of human rabies were diagnosed in the United States, and 38 of these were caused by rabies acquired in the United States. No U.S. cases occurred in people who had previously received rabies vaccine as pre-exposure prophylaxis.